ObeEnd is created over the groundwork of 30+ years of scientific research on obesity and weight loss. The data of which strongly display that PC6 stimulation would decreases gastric acid secretion and gastric contractility, suppressing food cravings. These effects would be optimal for weight management and improvement of overall health.
ObeEnd uses precise neuromodulation for nerve stimulation and post-exercise recovery. The device is currently undergoing its clinic-based research studies through collaboration with University of Michigan and Concordia University.
“Obesity develops only if energy intake, in the form of feeding, chronically exceeds total body expenditure. Energy expenditure includes physical activity, basal metabolism, and adaptive thermogenesis.” Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell. 2001 Feb 23;104(4):531-43.
“There were significant decrease in gastric acid output, serum gastrin concentration and AchE activity(P<0.05) after simultaneous acupuncture in Zhongwan, Neiguan and Sanyinjiao.” Wu YL, Chen SF, Pan LL. Effect of electroacupuncture on gastric acid secretion and gut hormones. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994 Dec;14(12):709-11.
“EAP at PC6 significantly reduced PDP to 47.2 ± 5.3% of baselines”
“PDP is associated with the gastric contractility, acupuncture-induced gastric relaxations are mediated via the inhibitory effect of EAP at PC6 on the PDP”
Electroacupuncture, EAP. period dominant power, PDP. Shiotani A, Tatewaki M, Hoshino E, Takahashi T. Effects of electroacupuncture on gastric myoelectrical activity in healthy humans. Neurogastroenterol Motil. 2004 Jun;16(3):293-8.
“The EGG recording of a subject performed EAP at PC6 (B). The amplitude was inhibited during EAP at PC6.” Shiotani A, Tatewaki M, Hoshino E, Takahashi T. Effects of electroacupuncture on gastric myoelectrical activity in healthy humans. Neurogastroenterol Motil. 2004 Jun;16(3):293-8.
“The acupuncture points PC 6 (Neiguan), that have been used for food cravings are also have the ability to reduce stress and suppress food cravings, making them optimal for controlling over consumption of foods in weight management programs.”
“It appears that acupuncture can increase the bioavailability of dopamine, which may act as an appetite suppressant. Controlling the levels of dopamine may mitigate food cravings, thus assisting with weight loss.” Martin BR. Complementary Medicine Therapies That May Assist With Weight Loss: A Narrative Review. J Chiropr Med. 2019 Jun;18(2):115-126.
“Taking together, our results firstly gave the experimental evidence that EA can remodel WAT to BAT through inducing UCP1 expression, and this may be one of the mechanisms by which acupuncture affects weight loss.”
“The ratio of the weight of WAT is a major tissue for excess energy storage. Acupuncture might promote Pparγ acetylation to increase UCP1 gene expression then inducing WAT browning” Shen W, Wang Y, Lu SF, et al. Acupuncture promotes white adipose tissue browning by inducing UCP1 expression on DIO mice. BMC Complement Altern Med. 2014 Dec 16;14:501.
“Acupuncture can reduce body weight, hip circumference, waist circumference and body mass index, which suggests that acupuncture is effective for the treatment of obesity” Zhang K, Zhou S, Wang C, Xu H, Zhang L. Acupuncture on Obesity: Clinical Evidence and Possible Neuroendocrine Mechanisms. Evid Based Complement Alternat Med. 2018 Jun 14;2018:6409389.